Synthesis of new, optically active 1-(substituted aryl)pyrrole derivatives via atropisomerism directed diastereoselective metalation
نویسندگان
چکیده
منابع مشابه
Facile synthesis of optically active imidazole derivatives.
Five optically active imidazole derivatives have been synthesized via a facile 4-step reaction sequence starting from commercially available and inexpensive N-Cbz amino acids. While microwave assisted condensation was unsuccessful, the condensation of the corresponding alpha-bromoketones with formamidine acetate in liquid ammonia was revealed to be a useful method for the synthesis of such imid...
متن کاملSynthesis of 1, 3-diaryl Substituted Iodobenzene Derivatives
The synthesis and characterization a new derivatives of 2'-iodo-meta terphenyl from the reaction ofexcess aryl-Grignard and 2, 6- dichloroiodobenzene with quenching of m-terphenyl-2'-magnesiumbromide by iodine is reported. Via the reactions three carbon-carbon bonds are constructed and mterphenylsare obtained in good yields.
متن کاملFacile synthesis of optically active gamma-lactones via lipase-catalyzed reaction of 4-substituted 4-hydroxybutyramides.
Lipase-catalyzed transesterification of racemic 4-substituted 4-hydroxybutyramides with succinic anhydride proceeded enantioselectively to afford (S)-succinic acid monoester and unreacted (R)-4-hydroxybutyramide derivative, which were separated easily by treatment with an alkaline solution. Both enantiomers were converted easily to optically active gamma-substituted gamma-butyrolactones.
متن کاملSynthesis of New Optically Active 3.5-DinitrosalicyloxazoIines
In the first homogeneous enantioselective catal ysis, a cyclopropanation reaction, Nozaki et al. used copper complexes of optically active salicylaldimines as the catalysts [2]. Systematic studies with such Schiff base complexes enabled Aratani et al. to achieve high optical yields in asymmetric cyclo propanation reactions [3,4], An industrial appli cation is the synthesis of a precursor of ...
متن کاملSynthesis of new optically active 2-pyrrolidinones.
A new class of optically active 2-pyrrolidinones was synthesized, starting from S-pyroglutamic acid, a well known natural chiral synthon. The synthetic design followed led to the insertion of various substituents at positions 1 and 5 of the 2-pyrrolidinone ring, including the imidazole moiety. Some of them possess two or three stereogenic centers, the configuration of which was retained under t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Arkivoc
سال: 2015
ISSN: 1551-7012
DOI: 10.3998/ark.5550190.p009.023